My Take On The 9 Best Quality Management Software Solutions

My top 9 quality management software recommendations for 2025

The best quality management software (QMS) is designed to help organizations ensure product quality, maintain compliance, and improve operational efficiency. As I evaluated these tools, I saw firsthand how they simplify document control, automate workflows, and enhance collaboration across teams, ensuring consistent and high-quality output.

What makes quality management software worth it: My opinion

• Support engineering change management for quality improvement
• Monitor nonconformance and out of specification products and components
• Provide a database of risk and compliance information and documentation
• Generate documents for incidents and quality control activities
• Provide training and certification to comply with quality standards and regulations
• Ensure quality and compliance for the fixed assets used by the company
• Include functionality to monitor supplier quality and performance
• Assist with corrective actions and preventive actions (CAPA) for quality issues
• Deliver customizable workflows and checklists for inspections and audits

This data was pulled from G2 in 2025. Some reviews have been edited for clarity.

1. MasterControl

MasterControl is widely recognized as a robust platform, particularly for businesses in the life sciences industry.

One feature that I see getting a lot of praise is its system validation, which is especially valuable in regulated industries. G2 users often highlight how MasterControl meets the strictest regulatory standards, with some pointing out its adoption by departments within the FDA. This validation is consistently noted as a key selling point for its credibility and reliability, making it a trusted choice for managing compliance in regulated industries.

Another aspect frequently appreciated by G2 reviewers is the integrated nature of the platform. According to feedback I gathered from G2 users, the system’s ability to centralize document management, training, audits, and quality events is highly valued. Users often emphasize how this integration eliminates the need for scattered paper files or multiple systems, making their workflow more efficient and reducing errors. This all-in-one system is particularly praised for streamlining operations and improving overall productivity.

One standout capability, according to users, is document management. G2 reviewers often mention how the system has simplified document storage, tracking, and access. This feature is seen as a major advantage, particularly for companies that were previously managing physical or disorganized digital files. Many users report that MasterControl significantly improves organization and productivity, contributing to a smoother operational flow.

Based on my review of G2 user feedback, the electronic signature functionality is another widely praised feature. For businesses with multiple locations or remote teams, this capability is essential, and users frequently highlight how MasterControl facilitates seamless collection of electronic signatures across different regions. Many G2 users from the US, Canada, and the UK appreciate how this feature saves time and ensures compliance with international standards.

However, there are some areas where MasterControl receives mixed reviews. From what I’ve seen, negative feedback tends to focus on the platform’s complexity for non-life sciences businesses. Many G2 reviewers mention that for organizations with fewer regulatory requirements or limited quality management processes, MasterControl can feel cumbersome. Specifically, some users express frustration with the system's detailed process modules, like the multi-step process for managing Corrective and Preventive Actions (CAPAs), which may feel excessive for companies that handle few quality events.

I’ve also come across noticeable dissatisfaction around MasterControl’s licensing structure. G2 users often point out that the distinction between "basic" and "full" licenses creates friction in the workflow, as only full license holders can collaborate on or approve documents. This setup, according to multiple reviewers, complicates user management and adds unnecessary complexity, especially in organizations with diverse licensing needs.

What I dislike about MasterControl:

• I’ve noticed that non-life sciences businesses often find MasterControl's complexity a barrier, with users noting its detailed process modules as cumbersome for companies with fewer regulatory requirements.
• Multiple reviewers have expressed dissatisfaction with MasterControl’s licensing structure, pointing out that the distinction between "basic" and "full" licenses creates workflow friction and complicates user management.

What G2 users dislike about MasterControl:

"Most of the software is centered around life sciences and the medical industry. This leads to the inclusion of many more checks and balances in the system than we require as a manufacturer that only seeks to meet to ISO 9001. There are configuration options available to fit our situation so this is only a minor issue."

- MasterControl Review, Travis B.

2. Qualio

Qualio is widely recognized as a solid tool for streamlining document management and approval processes.

One feature that G2 reviewers frequently highlight is the user interface, which is praised for being clean and intuitive. Many users mention how easy it is to navigate the platform, even for team members with minimal technical expertise. G2 feedback shows that the simplicity and clarity of the layout significantly improve the user experience, helping teams get up to speed quickly and use the platform efficiently.

Another element that G2 reviewers often appreciate is the review and approval functionality. Many users note how efficient and straightforward the process is for organizing and approving documents. This feature seems to stand out, with several reviewers mentioning that it significantly reduces complexity in document handling, making the overall process smoother and more manageable for teams.

I’ve noticed that document editing and collaboration within Qualio is another strong point in G2 reviews. G2 users consistently highlight how user-friendly this feature is, with many pointing out the ease of leaving comments and suggestions during the editing process. This feature is widely regarded as effective for improving document revisions, especially in complex projects where multiple feedback loops are common. The ability to manage change controls and create form templates is also frequently praised for saving time and streamlining documentation tasks.

Looking at G2 feedback, Qualio’s integration with Microsoft Suite is mentioned as a notable benefit. Users frequently comment on how easy it is to import documents from tools like Microsoft Word, with some mentioning minor formatting discrepancies. Despite these small issues, most G2 reviewers appreciate the seamless transition from familiar tools, making it easier to incorporate documents into Qualio without significant hassle.

However, there are areas where Qualio receives mixed reviews. A common theme in negative feedback revolves around the review and approval process, particularly when it comes to accepting suggestions or edits from reviewers. Multiple users on G2 have expressed frustration with the lack of a feature that allows them to accept edits without losing all the reviewer sign-off timestamps. This is seen as a significant issue for compliance, as it can disrupt the audit trail, which is crucial for maintaining proper documentation during audits.

Another pain point that G2 reviewers mention is document formatting. I’ve come across noticeable dissatisfaction around the platform’s limited formatting options compared to tools like Microsoft Word or Google Docs. Many users point out that the formatting can become messy, especially when fine-tuning documents, and this has caused frustration in maintaining a polished, professional look.

Lastly, document freezing is a recurring issue in G2 reviews. Users often mention that when multiple reviewers are involved and each one adds comments or suggestions, the document sometimes freezes. This disrupts collaboration and causes delays, particularly when real-time edits or feedback are needed, making it a significant workflow issue for teams that rely on smooth, continuous collaboration.

What I dislike about Qualio:

• I’ve noticed frustration from users regarding review and approval process, particularly the inability to accept edits without losing reviewer sign-off timestamps, which affects compliance and the audit trail.
• Multiple G2 reviewers have expressed dissatisfaction with document formatting, pointing out that the platform lacks flexibility compared to tools like Microsoft Word, leading to formatting issues.

What G2 users dislike about Qualio:

"The reporting capabilities are somewhat limited—you can get the basics, but for more complex metrics, you may find yourself working offline. Also, the change control workflows could benefit from a bit more flexibility for organizations with more customized approval processes. Lastly, while onboarding is generally smooth, the initial configuration requires a clear understanding of how your quality system maps into Qualio’s structure—otherwise, you may end up reorganizing later."

- Qualio Review, Verified User in Medical Devices

3. Ideagen Quality Management

After reviewing G2 user feedback on Ideagen Quality Management, I’ve found that it’s generally well-regarded for its ability to streamline quality management processes, particularly for maintaining ISO 9001 compliance.

A consistent theme in G2 reviews is how the platform simplifies tracking compliance across various departments, which saves time and ensures that operations run smoothly. Many users have expressed appreciation for the tool’s ability to help businesses stay aligned with international quality standards, a crucial feature for maintaining industry credibility.

One feature that I frequently see G2 reviewers highlight is the audit management capabilities. Users often praise how Ideagen Quality Management facilitates scheduling and managing audits, making it easier to maintain compliance and efficiency.

The integration of operational risk management tools is another standout aspect, with many reviewers noting how it helps identify potential issues before they escalate. This proactive approach seems to be a key factor in preventing operational disruptions, according to feedback from multiple users.

Another element that G2 users often call out is the tool's focus on uniformity across teams. The structured workflows and automated approvals ensure that all teams follow the same procedures, a feature that reviewers particularly appreciate for maintaining consistency and quality. From the feedback I gathered, employees value how clear and straightforward the platform's processes are, which directly contributes to better team performance and efficiency.

However, I’ve seen some users express frustration with the learning curve for new users. Many G2 reviewers mention how the platform’s wide range of features can be overwhelming for those who are new to the system. The onboarding process appears to be a challenge for some, and multiple users have mentioned that it takes time to fully understand and navigate the tool. This delay in adoption is often noted as a barrier, especially for larger teams who need to get up to speed quickly.

Based on my review of G2 feedback, reporting capabilities tend to draw mixed reactions. While some users find the out-of-the-box reports useful, others point out that the tool requires significant customization to truly meet specific business needs. Several reviewers have mentioned that getting the most out of the reporting tools requires additional time and effort to learn the customization options, which can be frustrating for those not familiar with the process.

What I dislike about Ideagen Quality Management:

• I’ve seen some users express frustration with the learning curve, particularly due to the platform’s broad range of features, which can be overwhelming for new users during onboarding.
• Based on my review of G2 feedback, reporting capabilities draw mixed reactions, with some users mentioning the need for significant customization to meet specific business needs, which can be time-consuming.

What G2 users dislike about Ideagen Quality Management:

"The back-end management/admin can be cumbersome and limited in some areas. Additionally, extracting data can be an issue, as we sometimes have to copy data to extract it, which includes unnecessary data."

- Ideagen Quality Management Review, Alex F.

4. ETQ Reliance QMS

After reviewing G2 user feedback on ETQ Reliance QMS, I’ve noticed that the platform is generally praised for its mobile accessibility.

Many G2 users highlight how the ability to access the system while on the go has been a major advantage for their teams. This feature is often mentioned as a productivity booster, as it allows staff to stay connected and engaged with critical processes even when they’re not at their desks. I’ve seen multiple reviewers express how important this flexibility is in today’s fast-paced, mobile-driven work environment.

Another feature that frequently comes up in G2 reviews is the community access through ETQ Campus. Users appreciate the live videos and webinars that allow them to deepen their understanding of the platform and stay up to date with new features and best practices. A recurring theme in the feedback is the value of the community for troubleshooting and expanding users' knowledge, which is seen as a great resource for ongoing learning. Many reviewers mention how helpful the platform's community-driven content has been in resolving issues and improving their overall experience.

Customer support is another area that G2 reviewers consistently give high marks. ETQ’s customer support team is often described as knowledgeable and responsive, making it easier for users to get assistance when needed. A common piece of feedback I’ve seen is that the support team’s willingness to work with users to address questions or problems significantly contributes to a smoother experience. This level of service seems to instill confidence in users, knowing that help is readily available.

On the flip side, I’ve read multiple reviewers mention frustrations with the lack of a general overview document or index. Users have pointed out that having an index with definitions of fields and sections tied to the search bar would be a great addition. This would provide quicker access to essential information when setting up the system or configuring new features, reducing the time spent gathering the necessary details. Many G2 users have expressed that the current lack of such a resource can make the initial setup more time-consuming.

Another point that stands out in user feedback is the challenge with exploring enhanced functionality within the system. While ETQ Reliance offers the flexibility to tailor the platform to specific use cases, some users note that this customization often requires a patient, incremental approach.

Reviews suggest that certain features are not as well-documented as users would prefer, leading to frustration when trying to maximize the system's potential. However, users seem to appreciate that ETQ’s team is always available to help work through challenges, which mitigates some of the frustration. Still, the learning curve around certain functions is a recurring point of concern.

What I dislike about ETQ Reliance QMS:

• I’ve read multiple reviews where users express frustration about the lack of a general overview document or index, which could streamline the initial setup and feature configuration.
• I’ve come across feedback mentioning the challenge of exploring advanced functionality, with users noting that the customization process often requires patience and more detailed documentation.

What G2 users dislike about ETQ Reliance QMS:

"Though many REST API features have been added, the documentation on API usage needs improvement. Some key features, such as the ability for users to save view filters and additional controls in view configuration and centralized reports, are still missing."

- ETQ Reliance QMS Review, Sangamesh P.

5. Greenlight Guru Quality Management System

Greenlight Guru Quality Management System is widely praised for its comprehensive coverage of quality management functions.

One feature that G2 users consistently highlight is the system's ability to handle a broad range of quality management processes. From document and change control to design controls, risk management, and continuous monitoring and improvement, many reviewers appreciate having a single platform to manage all these tasks. This integration is particularly valuable in the medical device industry, where compliance and risk management are essential. Many G2 reviewers emphasize how this centralized approach simplifies workflows and boosts efficiency.

Another point of praise I’ve seen from G2 reviewers is the user-friendly interface. Based on user feedback, many find the platform easy to learn, which made transitions smoother for teams adopting the system. I’ve read multiple G2 reviews where users mention that the simple interface helped them quickly navigate the platform and adapt to its features without a steep learning curve. This is often highlighted as a major benefit for teams that need to get up to speed quickly.

Automation is another feature G2 users frequently appreciate. Many users mention how Greenlight Guru allows them to customize the system according to their specific needs, which significantly reduces manual work. This automation feature has been particularly helpful for streamlining routine tasks, ensuring consistency, and improving accuracy. According to feedback, it’s considered a major time-saver by those who rely on the system for quality management processes.

The integration of pre-configured validation packages is another standout capability, as highlighted by G2 reviewers. Many users mention that these packages made it much easier to meet their QMS requirements without needing to spend time customizing from scratch. This is praised as a major convenience, particularly for teams looking to avoid unnecessary delays in their operations. Additionally, the module training videos received positive feedback for helping users quickly understand how to use the system effectively, allowing employees to start using the platform with confidence.

However, not all feedback is entirely positive. Based on my review of G2 user feedback, the onboarding process appears to be a point of frustration for some users. A few reviewers mentioned that uploading legacy documents into the system was cumbersome, particularly when done in batches. I’ve seen some users express frustration with this, wishing there had been a more efficient mass data upload option to expedite the transition and make the process smoother.

Another area that I’ve noticed G2 users point out as problematic is the inconsistency across workspaces. Multiple users have mentioned issues where some field entries require users to save changes manually, while others do not. This lack of uniformity seems to cause confusion and slow down workflows, according to feedback from several G2 reviewers. Additionally, the use of different data input formats, like RTF text boxes in some workspaces and not in others, has been noted as a source of frustration, affecting the overall consistency of the user experience.

What I dislike about Greenlight Guru Quality Management System:

• I’ve come across feedback where users express frustration with the cumbersome process of uploading legacy documents in batches, wishing for a more efficient mass data upload option.
• I’ve seen multiple users mention issues with inconsistency across workspaces, particularly the manual saving of field entries and varying data input formats, which creates confusion and hinders workflows.

What G2 users dislike about Greenlight Guru Quality Management System:

"The initial setup or migration to Greenlight Guru can feel cumbersome. Also, the email notifications can’t be sorted, leading to a flood of updates from all departments, even for items you're not involved with."

- Greenlight Guru Quality Management System Review, Sharath M.

6. SafetyCulture

After evaluating SafetyCulture based on user feedback from G2, I’ve noticed that many reviewers are highly satisfied with the tool's user-friendliness.

One consistent theme in the reviews is how intuitive the layout is, making it easy to navigate without requiring extensive training. G2 users frequently highlight how this ease of use is particularly beneficial for managing large amounts of equipment. For example, some users, like those managing thousands of pieces of equipment daily, report that SafetyCulture significantly streamlines their workflow, saving both time and effort.

Another feature that G2 reviewers frequently appreciate is the organization of the software. Based on the feedback I’ve reviewed, users seem to value how easy it is to upload data into vital reports. Many reviewers mention how quickly they can input necessary information and generate reports without getting bogged down by complicated steps. This simple and efficient process appears to make data handling less stressful and allows teams to stay accurate while focusing on other important tasks.

From what I’ve gathered from G2 feedback, SafetyCulture’s flexibility is another aspect that stands out. Reviewers often mention how the software can handle a variety of equipment types, from newer models to older ones, without feeling restrictive. Users appreciate how the platform accommodates different needs, from tracking maintenance schedules to ensuring compliance, and everything seems well-organized and easily accessible.

However, I’ve seen some G2 users express frustration with AI errors in the system, particularly when generating reports for work area analysis. Multiple reviewers mention that while the AI feature is generally helpful, it doesn’t always provide the most accurate insights, leading to occasional delays or errors in final reports. Based on this feedback, it seems that improving the accuracy of the AI would make SafetyCulture even more reliable for users.

Additionally, several G2 users note challenges with accessing historical data. Some teams, according to the feedback, struggled to recall old inspections when needed, as navigating through multiple screens wasn’t as intuitive as it could be. This seems to create frustration for users who need quick access to past inspections. I’ve seen a recurring suggestion from users that SafetyCulture could benefit from a more straightforward method for accessing historical data more efficiently.

What I dislike about SafetyCulture:

• I’ve seen several G2 users express frustration with AI errors when generating reports, noting occasional delays or inaccuracies in work area analysis that affect the reliability of the tool.
• I’ve come across feedback mentioning difficulty with accessing historical data, with users suggesting that a more intuitive method for retrieving past inspections could improve the overall experience.

What G2 users dislike about SafetyCulture:

"SafetyCulture is effective for high-level task tracking, but it could improve by offering more detailed feedback on completed inspections and making it easier to navigate and retrieve past inspections across multiple screens."

- SafetyCulture Review, Dona B.

7. QT9 QMS

What I dislike about QT9 QMS:

• I’ve come across dissatisfaction regarding the Customer Document Portal, with users noting that it lacks automatic notifications for customers, leading to inefficiencies in communication.
• I’ve seen several G2 users mention a need for more dashboard customization options, as greater flexibility in personalizing the dashboard would enhance usability for many users.

What G2 users dislike about QT9 QMS:

"The only downside I've experienced at this point is the lack of integration into our ERP. It's a standalone system that does have open API's, but it would be nice if it was compatable out-of-the-box."
- QT9 QMS Review, Joshua E.

8. AmpleLogic Electronic Quality Management System (eQMS)

What I dislike about AmpleLogic Electronic Quality Management System (eQMS):

• I’ve come across feedback highlighting the absence of system investigation and risk assessment features, which forces users to rely on external tools, creating inefficiencies and added complexity.
• I’ve seen some G2 reviewers mention dissatisfaction with the Audit Trail Reports, noting that improvements to these reports could enhance compliance capabilities and provide a more comprehensive history of actions.

What G2 users dislike about AmpleLogic Electronic Quality Management System (eQMS):

"The software lacks a draft-saving feature, preventing users from saving partially completed prepaid entries."
- AmpleLogic Electronic Quality Management System (eQMS) Review, Manilal P.

9. ZenQMS

What I dislike about ZenQMS:

• I’ve noticed that some G2 users find the Change Control and Issues workflows confusing, with suggestions for a more streamlined layout and better navigation.
• I’ve read feedback mentioning that the lack of the ability to add appendix numbers or integrate Key-ID numbers into document headers is seen as a significant limitation for users handling large documents.

What G2 users dislike about ZenQMS:

"My only complaint about the system currently is that I wish there was a way to arrange the assignments in a specific order, allowing users to follow the list in the order we want them to. I also wish there was a way to place tests and associated training modules together in an individual's dossier, so they don’t have to search for the associated documents."
- ZenQMS Review, Michelle W.

Quality management software: Frequently asked questions (FAQs)

1. Can quality management software help with regulatory compliance?

Yes. Most QMS platforms are designed to help organizations meet industry-specific regulatory requirements, such as FDA, ISO, and GMP standards, by automating compliance tracking, document management, and audit trails.

2. Which quality management software is ideal for large enterprises?

Software like MasterControl and ETQ Reliance is highly favored by large enterprises for their scalability, advanced reporting capabilities, and robust compliance features that meet global regulatory standards.

3. How long does it take to implement a QMS?

The implementation time can vary depending on the complexity of the platform, the size of the organization, and the customization required. On average, it can take anywhere from a few weeks to several months.

4. How does QMS support quality management in service-based industries?

In service-based industries, QMS can enhance quality management by standardizing service delivery processes, tracking customer feedback, ensuring compliance with industry standards, and managing corrective actions for customer complaints. It helps improve service consistency and client satisfaction.

5. How do I choose the best QMS for my organization?

When choosing a QMS, consider factors such as ease of use, customization options, scalability, integration capabilities, industry-specific features, customer support, and pricing. It’s also helpful to check for certifications and user reviews to ensure it aligns with your organizational goals.

Because good enough isn’t good enough

Poor quality doesn’t just impact your bottom line, it can permanently damage your company's reputation. One product recall, failed audit, or compliance violation can erode customer trust faster than it was built.

Each QMS platform I evaluated offers unique features tailored to different needs, whether you’re focused on preventing defects, streamlining audits, or managing corrective actions.

With so many strong options, there's no reason to leave your quality and reputation to chance. I hope my insights help you find your organization's best management software.

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